Science translational medicineAnimalsArmadillo Domain ProteinsCytoskeletal ProteinsNerve RegenerationAxons
Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury.
Ligia B Schmitd, Hannah Hafner, Ayobami Ward, Elham Asghari Adib, Natalia P Biscola, Rafi Kohen, Mitre Athaiya, Meghan Tuttle, Manav Patel, Rachel E Williamson, Emily Desai, Julianna Bennett, Grace Saxman, David Wilborn, Jaisha Shumpert
Published: 202510.1126/scitranslmed.adp9155
Abstract
Upon injury to the mammalian peripheral nervous system (PNS), severed axons undergo rapid SARM1-dependent programmed axon death (Wallerian degeneration), but a potential role for Sarm1 in PNS regeneration remains unclear. We show that in mouse dorsal…
Preview only. Read the full abstract at the source