Science translational medicineHumansAmyloidosisAmyloidMutationAnimals
Genetic and structural aspects of amyloid diseases.
Gregory M Rosenberg, Kevin A Murray, Michael R Sawaya, Yi Xiao Jiang, Daniel H Geschwind, David S Eisenberg
Published: 202510.1126/scitranslmed.adp3378
Abstract
The conversion of proteins into insoluble fibrillar aggregates known as amyloid occurs in a wide variety of diseases, e.g., Alzheimer's disease, amyotrophic lateral sclerosis, systemic transthyretin amyloidosis, and multisystem atrophy. There are mor…
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