Science translational medicineExodeoxyribonucleasesMacrophagesAnimalsPhosphoproteinsHumans
Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury.
Ahmed Gamal-Eldin Ibrahim, Alessandra Ciullo, Hiroaki Komuro, Kazutaka Miyamoto, Xaviar M Jones, Shukuro Yamaguchi, Kara Tsi, Jessica Anderson, Joshua Godoy Coto, Diana Kitka, Ke Liao, Chang Li, Alice Rannou, Asma Nawaz, Ashley Morris
Published: 202510.1126/scitranslmed.adp1338
Abstract
Noncoding RNAs (ncRNAs) are increasingly recognized as promising therapeutic candidates. Here, we report the development of therapeutic Y RNA 1 (TY1), a synthetic ncRNA bioinspired by a naturally occurring human small Y RNA with immunomodulatory prop…
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