Science translational medicineAnimalsReceptorsG-Protein-CoupledSwineMice
Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs.
Yaqi Zhang, Hui Huang, Yaying Wang, Xiang Li, Peizhou Hou, Miaorong Yu, Zhuan Zhang, Shiyan Guo, Chang Liu, Zilong Zhang, Yan Zhuo, Chunliu Zhu, Pengcheng Zhang, Shisheng Wang, Hu Zhou
Published: 202510.1126/scitranslmed.ado5177
Abstract
Numerous G protein-coupled receptors (GPCRs) expressed in the gastrointestinal tract serve as crucial transducers to regulate a variety of physiological functions upon activation. Takeda G protein-coupled receptor 5 (TGR5), a prominent gastrointestin…
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