Science translational medicineNon-alcoholic Fatty Liver DiseaseAnimalsTh17 CellsPolyaminesCell Differentiation
HIVEP1 aggravates NASH by reprogramming polyamine metabolism in TH17 cells.
Yidan Ren, Xiaoyan Liu, Maoxiao Feng, Jianxiong Zhao, Yangmiao Duan, Guoying Dong, Huiru Gao, Xiaodong Hao, Qin Wang, Jiaying Yao, Zan Yuan, Xu Jing, Jing Wu, Yihai Cao, Yunshan Wang
Published: 202510.1126/scitranslmed.adn1150
Abstract
Nonalcoholic steatohepatitis (NASH) is a chronic, inflammatory form of nonalcoholic fatty liver disease (NAFLD) that frequently progresses to cirrhosis and hepatocellular carcinoma (HCC). However, the role of various immune cells in switching from NA…
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