Science signalingAnimalsMethamphetamineMiceDopamine Plasma Membrane Transport ProteinsDopaminergic Neurons
TNF-α signaling mediates the dopaminergic effects of methamphetamine by stimulating dopamine transporters and L-type Ca2+ channels.
Landon M Lin, Marcelo Febo, Adriaan W Bruijnzeel, Leah Phan, Adithya Gopinath, Jordan Seibold, Emily Miller, Habibeh Khoshbouei
Published: 202510.1126/scisignal.ady8676
Abstract
The highly addictive psychostimulant methamphetamine increases the release of dopamine in the brain's reward circuitry, where it also promotes the release of cytokines, including TNF-α, that contribute to neuroinflammation associated with methampheta…
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