Science signalingAnimalsMicebeta Karyopherins3' Untranslated RegionsProtein Biosynthesis
Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory.
Philip A Freund, Nicolas Panayotis, PingAn Yuanxiang, Sebastian Samer, Leilah Otikovs, Riki Kawaguchi, Juan Oses-Prieto, Talieh Zomorrodinia, Ida Rishal, Michaela Schweizer, Michael Tsoory, Katarzyna M Grochowska, Anna Karpova, Alma L Burlingame, Michael R Kreutz
Published: 202610.1126/scisignal.ady2026
Abstract
Axonal localization and local translation of mRNA encoding importin β1 are important for retrograde injury signaling and axonal growth. Here, we found that loss of importin β1 in axons through deletion of the mRNA's 3' untranslated region (3'UTR) cau…
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