Science signalingHumansCryoelectron MicroscopyReceptorsG-Protein-CoupledLactic Acid
Structural insights into the activation mechanism of the human metabolite receptor HCAR1.
Mengru Gao, ShaoKun Zang, Yanqing Zhu, Kun Xi, Yage Du, Shizhuo Cheng, Luwei Miao, Yanhui Lu, Chunyou Mao, Yan Zhang, Xin Ma
Published: 202610.1126/scisignal.adw1483
Abstract
Hydroxycarboxylic acid receptor 1 (HCAR1) is a class A G protein-coupled receptor (GPCR) that is activated by the endogenous metabolite l-lactate and that plays an important role in various metabolic and inflammatory disorders. HCAR1 uses distinct li…
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