Science signalingAnimalsReceptorsN-Methyl-D-AspartateMorphineErbB Receptors
EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer.
Naijiang Liu, Xiaojie Shi, Shao-Rui Chen, Hong Chen, Maria Daniela Santi, Dong Minh Phuong, Maria Fernanda Pessano Fialho, Tongxin Xie, Frederico Gleber-Netto, Rocco Latorre, Nigel W Bunnett, Chi Viet, Moran Amit, Hui-Lin Pan, Yi Ye
Published: 202610.1126/scisignal.adt3026
Abstract
Pain associated with oral cancer is debilitating. Opioids are the gold standard for cancer pain management, but tolerance and side effects limit their use. Epidermal growth factor receptor (EGFR) signaling is commonly amplified in oral tumors. Here,…
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