Science signalingHeparan SulfateAnimalsGlycocalyxLeukocytesPsoriasis
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation.
Megan J Priestley, Anna K Hains, Iashia Z Mulholland, Sam Spijkers-Shaw, Joshua C Müller, Gareth Howell, Amanda J L Ridley, H Davies-Strickleton, Rebecca L Miller, Max Nobis, Olga V Zubkova, Amy E Saunders, Douglas P Dyer
Published: 202510.1126/scisignal.adr0011
Abstract
The glycocalyx is a proteoglycan-rich layer present on the surface of all mammalian cells and is particularly prevalent on endothelial cells lining the vasculature. The glycocalyx is thought to affect leukocyte migration by masking adhesion molecules…
Preview only. Read the full abstract at the source