Science signalingHumansReceptorsImmunologicMacrophagesLigands
The scavenger receptor MARCO is a ligand for the immune inhibitory receptor LAIR-1 and regulates its function in cis.
Akashdip Singh, Saskia V Vijver, Hajar Aglmous-Talibi, Nebojsa Jukic, Peirong Chen, Suzanne Crawley, Kalyani Mondal, Jing Zhou, Christian Niederauer, Zimple Matharu, Betty Li, Bin Fan, Michiel van der Vlist, Daniel D Kaplan, Lee B Rivera
Published: 202510.1126/scisignal.ado2768
Abstract
LAIR-1 is an inhibitory receptor on immune cells that recognizes collagens and collagen domain-containing proteins. The high abundance of both LAIR-1 and its ligands suggests tight regulation of this interaction. MARCO is a scavenger receptor with a…
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