Science immunologyNeutrophilsAcute Lung InjuryArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseAnimals
Siglec-F+ neutrophils promote the resolution of acute lung injury through ALOX15 induction.
Luciana P Tavares, Thayse R Brüggemann, R Elaine Cagnina, Robert Nshimiyimana, Ana B Villaseñor-Altamirano, Rafael M Rezende, Toby B Lanser, Xiaoli Liu, Marjorie E Bateman, Nandini Krishnamoorthy, Stephanie Pons, Melody G Duvall, Raja-Elie E Abdulnour, Alexander Tavares, Kathleen J Haley
Published: 202510.1126/sciimmunol.aeb2657
Abstract
Neutrophils have vital proinflammatory protective functions, but gene expression changes in neutrophils found in inflamed tissues suggest additional proresolving effects. We identified a neutrophil subset with a distinct phenotype and function that e…
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