Science immunologyAnimalsEarly Growth Response Protein 1NeutrophilsMiceInbred C57BL
Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity.
Tian-Gen Chang, Jay Friedman, Paul E Clavijo, Yvette Robbins, Marco Craveiro, Angel Huynh, Mohd Saleem Dar, Xinping Yang, Yingying Cao, Cem M Sievers, Christopher Silvin, Christian Samaniego Davila, Michael C Kelly, James W Hodge, Nancy P Judd
Published: 202510.1126/sciimmunol.adz2273
Abstract
Neutrophils frequently adopt immunosuppressive phenotypes in tumors, yet the underlying mechanisms remain incompletely understood. Here, we identify the transcription factor early growth response protein 1 (EGR1) as a key regulator of nuclear morphol…
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