Science immunologyAnimalsB-LymphocytesAntigensProtozoanProtozoan Proteins
B cells targeting parasites capture spatially linked antigens to secure T cell help.
Xin Gao, Hayley A McNamara, Jiwon Lee, Adrian F Lo, Deepyan Chatterjee, Dominik Spensberger, Daniel Fernandez-Ruiz, Kevin Walz, Ke Wang, Hannah G Kelly, Kai Pohl, Patricia E Carreira, Andrea Do, Le Xiong, Lynette Beattie
Published: 202510.1126/sciimmunol.adw0415
Abstract
T cell-dependent antibody responses have been well studied in the context of small proteins and viruses. However, how B cells acquire and process antigens from large pathogens such as parasites remains poorly understood. Here, using Plasmodium sporoz…
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