Science immunologyGerminal CenterSARS-CoV-2HumansAnimalsB-Lymphocytes
Germinal center-mediated broadening of B cell responses to SARS-CoV-2 booster immunization.
Sameer Kumar Malladi, Deepika Jaiswal, Baoling Ying, Wafaa B Alsoussi, Tamarand L Darling, Bernadeta Dadonaite, Alesandro Civljak, Stephen C Horvath, Julian Q Zhou, Wooseob Kim, Jackson S Turner, Aaron J Schmitz, Fangjie Han, Suzanne M Scheaffer, Christopher W Farnsworth
Published: 202510.1126/sciimmunol.adu4107
Abstract
Germinal centers (GCs) are key sites for antibody diversification and affinity maturation. SARS-CoV-2 messenger RNA (mRNA) vaccines elicit robust GC B cell responses in humans, but how these responses influence the breadth of immunity against viral v…
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