Science immunologyHumans2'5'-Oligoadenylate SynthetaseEndoribonucleasesCOVID-19
The OAS-RNase L pathway: Insights from experiments of nature.
Danyel Lee, Krishnamurthy Malathi, Tsubasa Okano, Koji Nakajima, Aurélie Cobat, Tomohiro Morio, Jean-Laurent Casanova, Shen-Ying Zhang
Published: 202610.1126/sciimmunol.ads9407
Abstract
The 2'-5' oligoadenylate synthetases (OASs) are type I interferon-inducible enzymes that, with ribonuclease L (RNase L), have been studied in the context of their coupled action as antiviral effectors. RNase L degrades host and viral ssRNA, affecting…
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