Science immunologyAnimalsFlagellinMiceInbred C57BLCrohn Disease
Divergent immune responses to commensal bacteria bearing distinct motility signatures.
Lennard W Duck, Melissa S Jennings, Jung-Shan Hsu, Covenant F Adeboboye, E Leighann Morgan, Kiarra J Coger, Barbara J Klocke, Dave D Hill, Katie L Alexander, Alexander F Rosenberg, Goo Lee, Qing Zhao, Charles O Elson, Craig L Maynard
Published: 202510.1126/sciimmunol.adp8843
Abstract
Adaptive immune responses to commensal flagellins are hallmarks of Crohn's disease (CD), but it is unclear whether flagellins themselves promote inflammation or whether flagellated commensals can also be colitogenic. Here, we show that the arrangemen…
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