Science (New York, N.Y.)AnimalsFemaleHumansMiceAldehydes
Three-component assembly and structure-function relationships of (-)-gukulenin A.
Vaani Gupta, Zechun Wang, Joshua B Combs, Timothy Wright, Lei Chen, Boxu Lin, Ryan Holmes, Bo Qin, Joonseok Oh, Jason M Crawford, Seth B Herzon
Published: 202510.1126/science.aea9310
Abstract
α-Tropolones comprise an unsaturated seven-membered ring bearing a hydroxyl substituent adjacent to a polarized carbon-oxygen π bond. This polarization imparts a permanent molecular dipole and aromatic stabilization to the ring, resulting in distinct…
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