Science (New York, N.Y.)AlkenesHydrogenationBiocatalysisOxidation-ReductionHeme
Biocatalytic, asymmetric radical hydrogenation of unactivated alkenes.
Jaicy Vallapurackal, Rajib Mandal, Justin Bossenbroek, Aris V Rubio, Ethan Poladian, James D Collings, Cesar Torres, Matthew Hendrickson, Julian Morales, Max B Lyons, Kyle Schultz, Hannah S Shafaat, K N Houk, Soumitra V Athavale
Published: 202510.1126/science.aea4737
Abstract
Alkene hydrogenation is a cornerstone of chemical synthesis, yet enzymatic strategies remain limited to electron-deficient substrates by means of hydride transfer. Using heme enzymes, we unlock a hydrogenation pathway for the asymmetric reduction of…
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