Science (New York, N.Y.)AnimalsHumansMiceAntigensNeoplasm
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity.
Bowen Xie, Bowen Yuan, Xiaohong Zhao, Tian Xie, Ruifeng Li, Peng Wei, Qinli Sun, Wenbo Hu, Birui Pan, Yongzhen Chen, Kun Wei, Zixuan Zhao, Lei Yuan, Xuan Zhong, Xue Bai
Published: 202510.1126/science.ady5362
Abstract
Conventional type 1 dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8+ T cells. How tumor antigens are processed to activate CD8+ T cell immunity is not well unders…
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