Science (New York, N.Y.)
Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration.
Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R Palla, Stuart Goodman, Helen M Blau, Nidhi Bhutani
Published: 202510.1126/science.adx6649
Abstract
Aging or injury to the joints can lead to cartilage degeneration and osteoarthritis (OA), for which there are limited effective treatments. We found that expression of 15-hydroxy prostaglandin dehydrogenase (15-PGDH) is increased in the articular car…
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