Science (New York, N.Y.)HumansMiceAnimalsAneuploidyMouse Embryonic Stem Cells
High-fidelity human chromosome transfer and elimination.
Gianluca Petris, Simona Grazioli, Linda van Bijsterveldt, Pierre Murat, Kim C Liu, Jakob Birnbaum, Julian E Sale, Jason W Chin
Published: 202510.1126/science.adv9797
Abstract
The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) the facile transfer of human chromosomes from human…
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