Science (New York, N.Y.)NucleosomesMolecular Dynamics SimulationCryoelectron MicroscopyChromatinHistones
Multiscale structure of chromatin condensates explains phase separation and material properties.
Huabin Zhou, Jan Huertas, M Julia Maristany, Kieran Russell, June Ho Hwang, Run-Wen Yao, Nirnay Samanta, Joshua Hutchings, Ramya Billur, Momoko Shiozaki, Xiaowei Zhao, Lynda K Doolittle, Bryan A Gibson, Andrea Soranno, Margot Riggi
Published: 202510.1126/science.adv6588
Abstract
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo-electron tomography and molecular dynamics simulations, we elucidated the structure of phase-separated chromatin condensates across…
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