Science (New York, N.Y.)AptamersNucleotideKineticsHumansHigh-Throughput Nucleotide Sequencing
SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling.
Guoyan Luo, Jia Song, Yongbo Fu, Yuanjie Jiang, Yuan Gao, Zhixing Zhong, Ling Li, Yong Wei, Hao-Ran Jia, Lu Guo, Ting Fu, Qin Wu, Weihong Tan
Published: 202610.1126/science.adv6127
Abstract
Cell surface proteins are key disease biomarkers and therapeutic targets, yet high-throughput methods for aptamer discovery targeting these proteins in situ remain limited. We introduce single-cell perturbation-driven aptamer recognition and kinetics…
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