Science (New York, N.Y.)AnimalsHumansMaleMiceBlood Platelets
Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation.
Charly Kusch, David Stegner, Lukas J Weiss, Paquita Nurden, Philipp Burkard, Denise Johnson, Wolfgang Bergmeier, Ceylan Onursal, Stefano Navarro, Christian Hackenbroch, Dennis Pfeiffer, Sabrina Ivana Bonfiglio, Mara Meub, Carina Gross, Joachim Schenk
Published: 202610.1126/science.adu2825
Abstract
Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma membrane extensions or "platelet-derived integrin-…
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