Science (New York, N.Y.)AnimalsMiceRegenerationCellular SenescenceMuscle
Cellular survivorship bias as a mechanistic driver of muscle stem cell aging.
Jengmin Kang, Daniel I Benjamin, Qiqi Guo, Chauncey Evangelista, Soochi Kim, Marina Arjona, Pieter Both, Mingyu Chung, Ananya K Krishnan, Gurkamal Dhaliwal, Richard Lam, Thomas A Rando
Published: 202610.1126/science.ads9175
Abstract
Aging is characterized by a decline in the ability of tissue repair and regeneration after injury. In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs) to efficiently contribute to muscle regeneration.…
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