Science (New York, N.Y.)HumansErbB ReceptorsGene Expression RegulationPhosphorylationProtein Domains
Direct targeting and regulation of RNA polymerase II by cell signaling kinases.
Preeti Dabas, Meritxell B Cutrona, Wojciech Rosikiewicz, Ryan P Kempen, Patrick Rodrigues, John Bowling, Mollie S Prater, Walter H Lang, Adithi Danda, Zhi Yuan, Beisi Xu, Shondra M Pruett-Miller, Gang Wu, Taosheng Chen, Aseem Z Ansari
Published: 202510.1126/science.ads7152
Abstract
Distinct phosphorylation marks are placed on the carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) during different stages of gene transcription. These phospho-CTD marks function as a molecular recognition code for the recruitment of stage…
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