Science (New York, N.Y.)AnimalsMaleMiceKnockoutNerve Tissue Proteins
The synaptic ectokinase VLK triggers the EphB2-NMDAR interaction to drive injury-induced pain.
Kolluru D Srikanth, Hajira Elahi, Praveen Chander, Halley R Washburn, Shayne Hassler, Juliet M Mwirigi, Moeno Kume, Jessica Loucks, Rohita Arjarapu, Rachel Hodge, Lucy He, Khadijah Mazhar, Stephanie I Shiers, Ishwarya Sankaranarayanan, Hediye Erdjument-Bromage
Published: 202510.1126/science.adp1007
Abstract
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the tyrosine-directed ectokinase, vertebrate lonesome k…
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