Science (New York, N.Y.)HumansChromatinDNA BreaksDouble-StrandedDNA Repair
Repair of DNA double-strand breaks leaves heritable impairment to genome function.
Susanne Bantele, Irene Mordini, Alva Biran, Nicolas Alcaraz, Gijs Zonderland, Alice Wenger, Nils Krietenstein, Anja Groth, Jiri Lukas
Published: 202510.1126/science.adk6662
Abstract
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is unknown whether the surrounding chromatin is resto…
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