Science (New York, N.Y.)HumansAlgorithmsDeep LearningDrug DiscoveryDrug Evaluation
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes.
Benjamin DeMeo, Charlotte Nesbitt, Samuel A Miller, Daniel B Burkhardt, Inna Lipchina, Doris Fu, Peter Holderrieth, David Kim, Sergey Kolchenko, Artur Szalata, Ishan Gupta, Christine Kerr, Thomas Pfefer, Raziel Rojas-Rodriguez, Sunil Kuppassani
Published: 202510.1126/science.adi8577
Abstract
Phenotypic drug screening remains constrained by the vastness of chemical space and the technical challenges of scaling experimental workflows. To overcome these barriers, computational methods have been developed to prioritize compounds, but they re…
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