Science advancesEscherichia coliKineticsPseudomonas aeruginosaAnti-Bacterial AgentsMembrane Transport Proteins
Efflux pumps control intracellular drug-target kinetics by limiting rebinding in bacteria.
Subrata Dev, Keiran Stevenson, Dai Le, Minsu Kim
Published: 202610.1126/sciadv.aea7983
Abstract
Bacterial efflux pumps are major contributors to multidrug resistance, classically described as "gatekeepers" that reduce drug entry. Here, we uncover a post-entry mechanism of efflux pumps, revealing their function deep into intracellular drug-targe…
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