Science advancesMaleCalcium ChannelsAnimalsSpermatozoaSperm Capacitation
CATSPERε extracellular domains are essential for sperm calcium channel assembly and activity modulation.
Jae Yeon Hwang, Huafeng Wang, Jong-Nam Oh, Jingon Kim, Sarah F Finnegan, Niels E Skakkebaek, Jean-Ju Chung
Published: 202610.1126/sciadv.adw3414
Abstract
The sperm flagellar-specific CatSper Ca2+ channel is a multiprotein complex critical for successful fertilization. The four ancillary subunits, CATSPERβ, γ, δ, and ε, form a unique canopy structure over the pore-forming channel. However, how the cano…
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