The Journal of physiology
PKMζ is necessary for long-term depression and long-term potentiation in the medial prefrontal cortex.
Alyssa R Kniffin, Erin A English, Lisa A Briand
Published: 202510.1113/JP289373
Abstract
PKMζ is an atypical, constitutively active protein kinase found exclusively in the nervous system. PKMζ is an AMPA receptor (AMPAR) trafficking protein that is involved in the insertion of GluA2-containing AMPARs in the synapse. As the trafficking of…
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