The Journal of physiology
Myosin motor dynamics and cardiac function: Insights from in vivo small-angle X-ray scattering and pressure-volume analysis.
James T Pearson, Mark T Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Nozomi Tokuhara, Kentaro Hirose, Md Junayed Nayeem, Yoshitaka Fujihara, Kohki Aoyama, Christoph Maack, Vasco Sequeira
Published: 202510.1113/JP287759
Abstract
Regulation of myosin motor extension and conformation is central to cardiac muscle contraction-relaxation, with myosin playing a critical role in mechanosensing during the cardiac cycle. Direct assessment of in vivo dynamic interplay between myosin h…
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