Experimental physiology
GABAB receptor-mediated modulation of sensory neuron excitability: Roles of CaV2.2, G-protein-coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels in human and mouse nociception.
Mariana Brizuela, Anuja R Bony, Sonia Garcia-Caraballo, David J Adams, Stuart M Brierley
Published: 202510.1113/EP093318
Abstract
Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage-gated calcium and potassium channels by G protein-coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic pept…
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