Experimental physiology
Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries.
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I Aldana, Hirotsugu Tsuchimochi, Mark T Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen
Published: 202510.1113/EP093296
Abstract
Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G-protein-coupled receptors and G12/RhoA/Rho kinase are im…
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