Experimental physiology
mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt-sensitive rats before puberty.
Sautan Mandal, Andrea K Brown, Ubong S Ekperikpe, Anukool A Bhopatkar, Krystle M Hughes, Tyler D Johnson, Jonita S Cooper, Konnor T Wilbert, Denise C Cornelius, Jan M Williams
Published: 202510.1113/EP092435
Abstract
Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt-sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined wheth…
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