Photochemistry and photobiology
Combination of iron chelator deferoxamine and ABCG2 transporter inhibitor lapatinib for therapeutic enhancement of 5-aminolevulinic acid.
Jordyn Olsen, Sharayu Chandratre, Lolwah Alsalamah, Daniel Merenich, Kenneth A Myers, Bin Chen
Published: 202510.1111/php.70057
Abstract
The use of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) for tumor fluorescence imaging and photodynamic therapy (PDT) may be limited by intrinsic PpIX-reducing mechanisms including PpIX bioconversion and efflux transport. The effectiv…
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