Photochemistry and photobiology
Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6-thioguanine.
André L Lopes, Fernanda M Prado, Helena C Junqueira, Marisa H G Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio
Published: 202510.1111/php.70044
Abstract
6-Thioguanine (6-TGua) is one of the thiopurines used as a cytostatic drug. When internalized by cells, 6-TGua is metabolized through the purine salvage pathway and readily incorporated into DNA. Patients treated with these thiopurines are more prone…
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