Pediatric dermatology
Laryngo-Onycho-Cutaneous Syndrome Managed With Thalidomide.
Ellen Chinchilli, Christopher J Yao, Maria R Cordisco
Published: 202510.1111/pde.70069
Abstract
Laryngo-onycho-cutaneous syndrome (LOCS), a subtype of junctional epidermolysis bullosa, results from mutations affecting laminin-332 subunits which alter epidermal-dermal adhesion. LOCS phenotype includes cutaneous, ocular, and laryngeal granuloma f…
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