Psychiatry and clinical neurosciences
Exploring brain structural effects of dopaminergic antagonism and partial agonism in antipsychotic-naïve patients with first-episode psychosis using normative modeling.
Anna Feveile, Karen S Ambrosen, Ketevan Shalikashvili, Jayachandra M Raghava, Mette Ø Nielsen, Kirsten B Bojesen, Barbora R Bučková, Andre F Marquand, Birte Y Glenthøj, Warda T Syeda, Bjørn H Ebdrup
Published: 202610.1111/pcn.70017
Abstract
AIM: Schizophrenia is associated with subtle brain structural alterations, but separating disease from medication effects is challenging. Antipsychotic dopamine D2 receptor (D2R) antagonism has been associated with striatal volume increases, but effe…
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