Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyHumansDiGeorge SyndromeMaleFemaleSingle-Cell Analysis
Single cell RNA-seq analysis of hematopoietic cell types in 22q11.2 deletion syndrome reveals significant changes to non-T cells.
Katherine Beigel, Nouf Alsaati, Kelly Maurer, Donna McDonald-McGinn, T Blaine Crowley, Montana Knight, Sarah E Henrickson, Anne S Bassett, Kathleen E Sullivan
Published: 202510.1111/pai.70237
Abstract
BACKGROUND: 22q11.2 Deletion syndrome is one of the most common inborn errors of immunity. There is a large body of literature supporting alterations to T cells as a result of thymic hypoplasia. Additional studies have supported changes to B cell beh…
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