Journal of neurochemistryAnimalsNeuroprotective AgentsRatsMaleMolecular Docking Simulation
Discovery and Characterization of Novel Spirotriazoloquinazolines as Potential Neuroprotectors: Synthesis, Computational Screening, and Preliminary In Vivo Evaluation.
Kostiantyn Shabelnyk, Lyudmyla Antypenko, Natalia Bohdan, Victor Ryzhenko, Igor Belenichev, Pavlo Petakh, Oleksandr Kamyshnyi, Serhii Kovalenko
Published: 202610.1111/jnc.70337
Abstract
This study describes the rational design, synthesis, and evaluation of forty 2'-R-6'H-spiro(cycloalkyl/heterocyclyl)[1,2,4]triazolo[1,5-c]quinazolines as potential neuroprotective agents targeting multiple receptor systems implicated in cognitive dys…
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