Journal of neurochemistryAnimalsTubulinAcetylationCaenorhabditis elegansSynaptic Vesicles
A Mutation in Vesicular Acetylcholine Transporter Increases Tubulin Acetylation Compromising Synaptic Vesicle Transport.
Cheng-Shan Kuo, Vignesh Mahendran Ruckmani, Meng-Chieh Wang, Muhammad Safwan Khawaja, Odvogmed Bayansan, Syed Nooruzuha Barmaver, Prerana Bhan, Oliver Ingvar Wagner
Published: 202510.1111/jnc.70322
Abstract
Kinesin-3 UNC-104(KIF1A) is the major anterograde axonal transporter of synaptic vesicles and is expressed pan-neuronally. Genetic defects in this molecular motor are linked to KIF1A-associated neurological disorders (KAND), a spectrum of severe neur…
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