Journal of neurochemistryAnimalsPurkinje CellsMiceProtein Kinase CDependovirus
Age-Progressive Synaptic and Axonal Dysregulation Induced by Purkinje Cell-Targeted AAV Expression of SCA14 PKCγ in Mice.
Naoko Adachi, Izumi Koganemaru, Feng Wanying, Naoya Matsushita, Tomoyoshi Nakayama, Takahiro Seki, Ayumu Konno, Hirokazu Hirai, Naoaki Saito, Takehiko Ueyama
Published: 202510.1111/jnc.70305
Abstract
Spinocerebellar ataxia type 14 (SCA14) is an autosomal-dominant disorder caused by more than 80 PRKCG missense variants encoding protein kinase Cγ (PKCγ), a serine/threonine kinase highly enriched in Purkinje cells (PCs). Despite typically late onset…
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