Journal of neurochemistryAnimalsHuntington DiseaseOxidative StressBrain-Derived Neurotrophic FactorMitochondria
BDNF Mitigates Early Oxidative Stress and Promotes Release of Neuroprotective Mitochondria From Striatal Astrocytes of zQ175 Huntington's Disease Mice.
Federico López Couselo, Julieta Saba, María Friser Frederiksen, Mateo Palmieri, Ana Clara Romero, María Mercedes Bigi, Lila Carniglia, Daniela Durand, Mercedes Lasaga, Carla Caruso
Published: 202510.1111/jnc.70276
Abstract
Huntington's disease (HD) is a neurodegenerative disorder characterized by mutant huntingtin (mHTT) aggregation, striatal neuron degeneration, astrocyte dysfunction, and accompanied by oxidative stress and mitochondrial impairment. We previously demo…
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