Journal of the American Geriatrics Society
Pharmacologic Modulation of Circadian Rhythms for Delirium Prevention: An Age-Stratified Systematic Review and Meta-Analysis.
Helen Michaela de Oliveira, Mariano Gallo Ruelas, Tariq Parker, Camilo André Viana Diaz, Guilherme Oliveira de Paula, Fernanda Valeriano Zamora, Pablo Ramon Fruett da Costa
Published: 202610.1111/jgs.70305
Abstract
BACKGROUND: Disturbances in sleep-wake homeostasis (Process S) and circadian rhythm (Process C) are common precipitants of delirium, especially among older hospitalized adults. We conducted a systematic review and meta-analysis to test whether four s…
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