Varespladib Alleviates Colonic Inflammation Induced by High-Fat Diet via Downregulating the TGF-β/Smad Pathway and AA Pathway by Inhibiting sPLA2.

BACKGROUND AND AIM: High-fat diets (HFD) increase the risk of colonic inflammation. Varespladib, an sPLA2 inhibitor, has shown potential to treat a variety of inflammatory diseases. Its role in colonic inflammation caused by a HFD remains to be studi…

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