Hepatology research : the official journal of the Japan Society of Hepatology
Dual Escape From Disulfidptosis and Ferroptosis Drives Highly Aggressive, Hypermetabolic Hepatocellular Carcinoma.
Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Shinichi Aishima, Yoshinao Oda, Tomoharu Yoshizumi
Published: 202610.1111/hepr.70116
Abstract
AIM: The cystine/glutamate antiporter xCT facilitates cystine uptake and glutathione synthesis and suppresses ferroptosis. However, its role in hepatocellular carcinoma (HCC), particularly in glucose metabolism and disulfidptosis, remains unclear. We…
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