Genes to cells : devoted to molecular & cellular mechanismsPorphobilinogen SynthaseHumansNeoplasmsCell ProliferationEpithelial-Mesenchymal Transition
Deficiency of δ-Aminolevulinate Dehydratase Confers a Survival Advantage and Drives Malignancy in Cancer.
Seiya Watanabe, Taku Chibazakura
Published: 202610.1111/gtc.70082
Abstract
Heme synthesis has been considered essential, yet cancer cells paradoxically maintain high proliferation despite suppressing the pathway, with low expression of δ-aminolevulinate dehydratase (ALAD), the second enzyme of the pathway, which correlates…
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